Doctors can pursue many career paths, including private practice, university-hospital work, or a job with a health maintenance organization. The first lets the physician be his own boss. The second offers him the opportunity to divide his work between treatment, research and instruction, in varying proportions. The third means he work for a large corporation, which provides him with patients and handles most of the administrative and business tasks that physicians in private practice have to handle on their own. Doctors can also work in inner-city clinics or in rural areas, where shortages of doctors exist. Doctors can be general practitioners or they can specialize in internal medicine, cardiology, endocrinology, neurology, oncology, sports medicine, or one of the many other specialties. Medicine is a very rewarding profession, but it is hard work. Doctors are often exhilarated when they know they have helped someone get well and devastated when they lose a patient. It is a job that can prey upon a physician physically and mentally.